Endocrine Abstracts

Objective: To evaluate the hydrolytical activity of autoantibodies (Ab) to double-stranded DNA using atomic force microscopy in patients with autoimmune thyroiditis.Methods: Ab to double-stranded DNA (dsDNA) IgG class were isolated from the serum of patients with autoimmune thyroiditis by DNA-affinity chromatography. Hydrolytical activity of Ab to dsDNA was confirmed by Polyacrylamide Gel Electrophoresi (PAGE). The images of Ab to dsDNA and results of ds...